Cymbalta (duloxetine) is an SSNRI treating major depression, generalized anxiety, diabetic neuropathic pain, fibromyalgia, and chronic musculoskeletal pain. Common side effects include nausea, drowsiness, dry mouth, and dizziness; one in six people discontinue due to side effects. Cymbalta (duloxetine) is used to treat major depressive disorder, general anxiety disorder and fibromyalgia. Includes Cymbalta side effects, interactions and indications. Duloxetine (Cymbalta) is a moderately priced drug used to treat depression, anxiety, fibromyalgia, and nerve pain associated with diabetes (diabetic peripheral neuropathy). It is more popular than comparable drugs. As of 2013, it is available in generic and brand versions. Duloxetine, sold under the brand name Cymbalta among others, [1] is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive–compulsive disorder, fibromyalgia, neuropathic pain, and other types of chronic pain. [9][10] It is taken by mouth. [9] Duloxetine belongs to a group of medicines known as selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). These medicines are thought to work by increasing the activity of chemicals called serotonin and norepinephrine in the brain. Duloxetine (Cymbalta) helps treat depression and anxiety. It can also help with some types of chronic pain, such as nerve pain from diabetes. Duloxetine (Cymbalta) is a type of antidepressant called an SNRI, or serotonin and norepinephrine reuptake inhibitor. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain. Duloxetine is available under the following different brand and other names: Cymbalta. While the brand-name capsule is no longer manufactured or dispensed at pharmacies, its identical generic version, duloxetine, remains widely available. The generic name for Cymbalta is duloxetine hydrochloride, commonly abbreviated as duloxetine HCl. Since the U.S. patent expired in 2013, multiple manufacturers produce generic duloxetine in 20 mg, 30 mg, and 60 mg delayed-release capsules. Find patient medical information for Duloxetine (Cymbalta, Drizalma Sprinkle) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings.