Duloxetine, sold under the brand name Cymbalta among others, [1] is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive–compulsive disorder, fibromyalgia, neuropathic pain, and other types of chronic pain. [9][10] It is taken by mouth. [9] Find patient medical information for Duloxetine (Cymbalta, Drizalma Sprinkle) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings While the brand-name capsule is no longer manufactured or dispensed at pharmacies, its identical generic version, duloxetine, remains widely available. Duloxetine belongs to a group of medicines known as selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). These medicines are thought to work by increasing the activity of chemicals called serotonin and norepinephrine in the brain. Generic Name: duloxetine. Drug Class: Antidepressants, SNRIs. What is duloxetine (Cymbalta) and what is it used for? Duloxetine (Cymbalta) is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant used for treating depression, anxiety disorder, and pain. Duloxetine (Cymbalta) helps treat depression and anxiety. It can also help with some types of chronic pain, such as nerve pain from diabetes. Duloxetine (Cymbalta) is a type of antidepressant called an SNRI, or serotonin and norepinephrine reuptake inhibitor. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain. Duloxetine is available under the following different brand and other names: Cymbalta. As of early 2026, generic Duloxetine delayed-release capsules are generally available from multiple manufacturers. There is no formal, widespread shortage of standard Duloxetine capsules listed by the FDA or ASHP. Cymbalta (duloxetine) is used to treat major depressive disorder, general anxiety disorder and fibromyalgia. Includes Cymbalta side effects, interactions and indications. It’s also available in a brand-name version called Cymbalta. Duloxetine oral capsules are a generic drug, which means they’re an exact copy of the active ingredient in a brand-name medication.