Detailed dosage guidelines and administration information for Cymbalta (duloxetine hydrochloride). Includes dose adjustments, warnings and precautions. Find patient medical information for Duloxetine (Cymbalta, Drizalma Sprinkle) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Cymbalta (duloxetine) is used to treat major depressive disorder, general anxiety disorder and fibromyalgia. Includes Cymbalta side effects, interactions and indications. While the brand-name capsule is no longer manufactured or dispensed at pharmacies, its identical generic version, duloxetine, remains widely available. Cymbalta (duloxetine) is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for treating depression, anxiety disorder, and pain associated with diabetic peripheral neuropathy or fibromyalgia. What Are Side Effects of Cymbalta? Cymbalta may cause serious side effects including: Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain. Duloxetine is available under the following different brand and other names: Cymbalta. Duloxetine (Cymbalta) helps treat depression and anxiety. It can also help with some types of chronic pain, such as nerve pain from diabetes. Duloxetine (Cymbalta) is a type of antidepressant called an SNRI, or serotonin and norepinephrine reuptake inhibitor. Duloxetine belongs to a group of medicines known as selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). These medicines are thought to work by increasing the activity of chemicals called serotonin and norepinephrine in the brain. Cymbalta (duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It’s used to treat depression, anxiety, and certain nerve or muscle pain conditions. The generic name for Cymbalta is duloxetine hydrochloride, commonly abbreviated as duloxetine HCl. Since the U.S. patent expired in 2013, multiple manufacturers produce generic duloxetine in 20 mg, 30 mg, and 60 mg delayed-release capsules.